Resident Evil 6 has four difficulties available from the start: Amateur, Normal, Veteran and Professional. Completing a campaign on Professional unlocks a fifth difficulty for that campaign called ‘No Hope’. There are various statistics tweaked depending on the difficulty:

• Amateur difficulty performs quick time events (QTE’s) for you automatically.
  On higher difficulties, enemies will be stronger in the following aspects:

• Enemies attack more frequently.

• Enemies move faster.

• Enemies stand up faster after being floored.

• Enemies hit more often during multi-hit attacks.

• The chance that a J’avo mutates increases.

• Stunning/Dazing enemies is harder; chance for this decreases.

• The interval between enemy fire is shorter. In other words, enemies wait less long before shooting again.

• Duration of a stun/daze is shorter for both gunshots and flash grenades.

• Enemies have better accuracy and will hit you more frequently as a result.

• Grapple attacks are greatly sped up and thus have a higher chance of actually grabbing you.

• You incur more hits and damage during grapple attacks.

• Rasklapanjes recover more quickly after their temporary death.